If you spend a lot of time on your feet, you most likely already have large calluses on your soles. These thickened areas of skin, which can also occur on your hands, are the result of repeated friction, irritation or pressure on your skin. Luckily, these toughened skin patches are relatively easy to remove. You can choose to soften the skin using moisturizers, soak the affected area in water, or attack the problem head on using a pumice stone.